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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine causes permanent symptoms of Parkinson's disease. (–)-Mitragynine is a naturally occurring tetrahydropyridine. 2,3,4,5-Tetrahydropyridine, a colorless liquid, is commercially available. It is an imine. Illustrating another isomer of tetrahydropyridine, 6-acetyl-2,3,4,5-tetrahydropyridine occurs ...
6-Acetyl-2,3,4,5-tetrahydropyridine and 2-acetyl-1-pyrroline are usually formed by Maillard reactions during heating of food. Both compounds have odor thresholds below 0.06 ng/L. Structure and properties. 6-Acetyl-2,3,4,5-tetrahydropyridine is a substituted tetrahydropyridine and a cyclic imine as well as a ketone. The compound exists in a ...
MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is an organic compound. It is classified as a tetrahydropyridine. It is of interest as a precursor to the neurotoxin MPP +, which causes permanent symptoms of Parkinson's disease by destroying dopaminergic neurons in the substantia nigra of the brain. It has been used to study disease models ...
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a widely used neurotoxin in Parkinson's disease research (Figure 4). In contrast to 6-OHDA, MPTP crosses the BBB which making the neurotoxin even more selective for dopaminergic neurons. Due to the ability to cross the blood-brain-barrier, MPTP is administered peripherally, subcutaneously.
SIB-1553A. Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). SIB-1553A is a nicotinic acetylcholine receptor agonist that is selective for receptors with a β 4 subunit. Administration of SIB-1553A improved memory and attention in a Parkinson's disease model. [1]
The 3 substrates of this enzyme are succinyl-CoA, (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate, and H 2 O, whereas its two products are CoA and N-succinyl-L-2-amino-6-oxoheptanedioate. This enzyme belongs to the family of transferases , specifically those acyltransferases transferring groups other than aminoacyl groups.
In enzymology, a tetrahydrodipicolinate N-acetyltransferase ( EC 2.3.1.89) is an enzyme that catalyzes the chemical reaction. The 3 substrates of this enzyme are acetyl-CoA, (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate, and H 2 O, whereas its two products are CoA and L-2-acetamido-6-oxoheptanedioate. This enzyme belongs to the family of ...
Methylphenyltetrahydropyridine N-monooxygenase. Methylphenyltetrahydropyridine N-monooxygenase ( EC 1.13.12.11) is an enzyme with systematic name 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine:oxygen N-oxidoreductase. [1] This enzyme catalyses the following chemical reaction. Methylphenyltetrahydropyridine N-monooxygenase is a flavoprotein.