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Breast cancer is a cancer that develops from breast tissue. [ 7] Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, milk rejection, fluid coming from the nipple, a newly inverted nipple, or a red or scaly patch of skin. [ 1] In those with distant spread of the disease, there may be bone pain ...
BRCA-related breast cancer appears at an earlier age than sporadic breast cancer. [9]: 89–111 It has been asserted that BRCA-related breast cancer is more aggressive than normal breast cancer, however most studies in specific populations suggest little or no difference in survival rates despite seemingly worse prognostic factors. [11] [12] [13]
All four types of breast cancer were found to have an average of about 100-fold increase in miR-182, compared to normal breast tissue. [74] In breast cancer cell lines, there is an inverse correlation of BRCA1 protein levels with miR-182 expression. [73]
There is some controversy as to whether these cancer cells travel through the ductal system of the breast to the nipple, [9] or whether these cells result from in situ malignant transformation. [ 2 ] The most widely accepted theory of how Paget's disease of the breast arises is the migratory theory: ductal carcinoma in situ cancerous cells ...
Metastatic breast cancer. Metastatic breast cancer, also referred to as metastases, advanced breast cancer, secondary tumors, secondaries or stage IV breast cancer, is a stage of breast cancer where the breast cancer cells have spread to distant sites beyond the axillary lymph nodes. There is no cure for metastatic breast cancer; [ 1] there is ...
Cancer cell. Cancer cells are cells that divide continually, forming solid tumors or flooding the blood or lymph with abnormal cells. Cell division is a normal process used by the body for growth and repair. A parent cell divides to form two daughter cells, and these daughter cells are used to build new tissue or to replace cells that have died ...
Adenocarcinoma is the malignant counterpart to adenoma, which is the benign form of such tumors. Sometimes adenomas transform into adenocarcinomas, but most do not. Well- differentiated adenocarcinomas tend to resemble the glandular tissue that they are derived from, while poorly differentiated adenocarcinomas may not.
Breast cancer stem cell. Breast cancer is the most prevalent type of cancer among women globally, with 685,000 deaths recorded worldwide in 2020. [1] The most commonly used treatment methods for breast cancer include surgery, radiotherapy and chemotherapy. [2] Some of these treated patients experience disease relapse and metastasis.
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