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Rheumatoid arthritis ( RA) is a long-term autoimmune disorder that primarily affects joints. [1] It typically results in warm, swollen, and painful joints. [1] Pain and stiffness often worsen following rest. [1] Most commonly, the wrist and hands are involved, with the same joints typically involved on both sides of the body. [1]
Rheumatoid factor ( RF) is the autoantibody that was first found in rheumatoid arthritis. It is defined as an antibody against the Fc portion of IgG and different RFs can recognize different parts of the IgG-Fc. [1] RF and IgG join to form immune complexes that contribute to the disease process such as chronic inflammation and joint destruction ...
Anti-citrullinated protein antibodies ( ACPAs) are autoantibodies ( antibodies to an individual's own proteins) that are directed against peptides and proteins that are citrullinated. They are present in the majority of patients with rheumatoid arthritis. Clinically, cyclic citrullinated peptides (CCP) are frequently used to detect these ...
As of 2020, about 17.6 million people worldwide have the autoimmune disease rheumatoid arthritis. Past studies have linked rheumatoid arthritis to an increased risk for a number of health concerns.
Rheumatism [2] or rheumatic disorders are conditions causing chronic, often intermittent pain affecting the joints or connective tissue. [3] Rheumatism does not designate any specific disorder, but covers at least 200 different conditions, including arthritis and "non-articular rheumatism", also known as "regional pain syndrome" or "soft tissue ...
Juvenile idiopathic arthritis ( JIA ), formerly known as juvenile rheumatoid arthritis ( JRA ), [ 1] is the most common chronic rheumatic disease of childhood, affecting approximately 3.8 to 400 out of 100,000 children. [ 3] Juvenile, in this context, refers to disease onset before 16 years of age, while idiopathic refers to a condition with no ...
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