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The nucleocapsid (N) protein is a protein that packages the positive-sense RNA genome of coronaviruses to form ribonucleoprotein structures enclosed within the viral capsid. [ 2][ 3] The N protein is the most highly expressed of the four major coronavirus structural proteins. [ 2] In addition to its interactions with RNA, N forms protein ...
Treatment and management of COVID-19. The treatment and management of COVID-19 combines both supportive care, which includes treatment to relieve symptoms, fluid therapy, oxygen support as needed, [ 1][ 2][ 3] and a growing list of approved medications. Highly effective vaccines have reduced mortality related to SARS-CoV-2; however, for those ...
Before 24 February 2020, over 95% of all deaths from COVID-19 worldwide had occurred in Hubei province, where Wuhan is located. [183] [184] As of 10 March 2023, ...
COVID-19 is the deadliest pandemic in US history; [359] it was the third-leading cause of death in the US in 2020, behind heart disease and cancer. [360] From 2019 to 2020, US life expectancy dropped by 3 years for Hispanic Americans, 2.9 years for African Americans, and 1.2 years for white Americans. [361]
The function of the spike glycoprotein is to mediate viral entry into the host cell by first interacting with molecules on the exterior cell surface and then fusing the viral and cellular membranes. Spike glycoprotein is a class I fusion protein that contains two regions, known as S1 and S2, responsible for these two functions.
The timeline of the COVID-19 pandemic lists the articles containing the chronology and epidemiology of SARS-CoV-2, [ 1] the virus that causes the coronavirus disease 2019 ( COVID-19) and is responsible for the COVID-19 pandemic . The first human cases of COVID-19 occurred in Wuhan, People's Republic of China, on or about 17 November 2019. [ 2]
v. t. e. The symptoms of COVID-19 are variable depending on the type of variant contracted, ranging from mild symptoms to a potentially fatal illness. [ 1][ 2] Common symptoms include coughing, fever, loss of smell (anosmia) and taste (ageusia), with less common ones including headaches, nasal congestion and runny nose, muscle pain, sore throat ...
This brought the total confirmed U.S. deaths due to coronavirus to 22: 19 in Washington, 1 in California, and 2 in Florida. Hawaii: Second case is reported by Governor David Ige and State health officials is an elderly man who tested positive after returning from travel to Washington state earlier in the month.