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Hydrocodone is only pharmaceutically available as an oral medication. [2] It is well-absorbed, but the oral bioavailability of hydrocodone is only approximately 25%. [4] [5] The onset of action of hydrocodone via this route is 10 to 20 minutes, with a peak effect (T max) occurring at 30 to 60 minutes, [51] and it has a duration of 4 to 8 hours. [2]
Absorption/distribution: The oral formulation can be absorbed from the gastrointestinal tract and remain 20–50% bound to plasma proteins. [15] The onset of analgesia is about 20 to 30 minutes with duration of 4 to 8 hours and t 1/2 of 3 to 4 hours. [15] Maximum serum levels are achieved at 1.3 hours. [16]
[1] [2] It contains hydrocodone, as the bitartrate, an opioid agonist; and homatropine, as the methylbromide, a muscarinic antagonist. [ 1 ] [ 2 ] It is taken by mouth . [ 1 ] [ 2 ]
Hydrocodone/ibuprofen , sold under the brand name Vicoprofen, is a fixed-dose combination analgesic medication used in short-term therapy to relieve severe pain. [ 3 ] [ 4 ] Vicoprofen combines the analgesic and antitussive properties of hydrocodone with the analgesic, anti-inflammatory, and antipyretic properties of ibuprofen . [ 1 ]
Benzhydrocodone. Benzhydrocodone ( INN) (contracted from benz oate - hydrocodone) is an opioid prodrug of the morphinan class. Its chemical structure consists of hydrocodone coupled with benzoic acid. Benzhydrocodone itself is inactive and acts as a prodrug to hydrocodone upon cleavage of the benzoate portion of the molecule. [ 1]
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