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Diabetes medication. Drugs used in diabetes treat diabetes mellitus by decreasing glucose levels in the blood. With the exception of insulin, most GLP-1 receptor agonists ( liraglutide, exenatide, and others), and pramlintide, all diabetes medications are administered orally and are thus called oral hypoglycemic agents or oral antihyperglycemic ...
[15] [29] Metformin is on the World Health Organization's List of Essential Medicines, [30] and is the most widely used medication for diabetes taken by mouth. [28] It is available as a generic medication. [15] In 2021, it was the second most commonly prescribed medication in the United States, with more than 91 million prescriptions. [31] [32]
SGLT2 inhibitor. SGLT2 inhibitors (also called gliflozins or flozins) are a class of medications that inhibit sodium-glucose transport proteins in the nephron (the functional units of the kidney ), unlike SGLT1 inhibitors that perform a similar function in the intestinal mucosa. The foremost metabolic effect of this is to inhibit reabsorption ...
In the SURMOUNT-1 trial, Lilly gave nearly 2,000 volunteers with pre-diabetes and obesity or overweight the drug at one of three different doses and 640 people a placebo and lifestyle counseling ...
Treatment with tirzepatide, the chemical name for Lilly's obesity drug Zepbound and diabetes treatment Mounjaro, resulted in an average weight reduction of 22.9%, compared to just 2.1% for the ...
The last few years have seen a marked increase in the use of glucagon-like peptide-1 receptor agonists (GLP-1 agonists) used for managing type 2 diabetes and as a way to lose weight. This rapid ...
Liraglutide. NMR structure of liraglutide. PDB entry 4apd . Liraglutide, sold under the brand names Victoza and Saxenda among others, is an anti-diabetic medication used to treat type 2 diabetes, and chronic obesity. [ 6][ 7] It is a second-line therapy for diabetes following first-line therapy with metformin. [ 6][ 8] Its effects on long-term ...
GLP-1 agonists were developed initially for type 2 diabetes. [5] The 2022 American Diabetes Association (ADA) standards of medical care in diabetes include GLP-1 agonist or SGLT2 inhibitor as a first line pharmacological therapy for type 2 diabetes in patients who have or are at high risk for atherosclerotic cardiovascular disease or heart failure.
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