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Phentermine (phenyl-tertiary-butyl amine), sold under the brand name Ionamin among others, is a medication used together with diet and exercise to treat obesity. [3] It is taken by mouth for up to a few weeks at a time, after which the benefits subside. [ 3 ]
Phentermine and topiramate was developed by Vivus, a California pharmaceutical company. In December 2009, Vivus, Inc. submitted a new drug application (NDA) to the FDA and on 1 March 2010, Vivus, Inc. announced that the FDA accepted the NDA for review.
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In 1984, researchers at the University of Rochester Medical Center reported that they had performed a double-blind, controlled clinical trial comparing phentermine alone, fenfluramine alone, a combination of phentermine and fenfluramine, and placebo, for weight loss in humans. Weight loss in those receiving the fen-phen combination was ...
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Fenfluramine is a substituted amphetamine and is also known as 3-trifluoromethyl- N -ethylamphetamine. [ 8] It is a racemic mixture of two enantiomers, dexfenfluramine and levofenfluramine. [ 8] Some analogues of fenfluramine include norfenfluramine, benfluorex, flucetorex, and fludorex .
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