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Ciclosporin is indicated to treat and prevent graft-versus-host disease in bone marrow transplantation and to prevent rejection of kidney, heart, and liver transplants. [8] [7] It is also approved in the US for treating of rheumatoid arthritis and psoriasis, persistent nummular keratitis following adenoviral keratoconjunctivitis, [23] [7] and as eye drops for treating dry eyes caused by ...
Ciclosporin, steroid eye drops [ 2] Frequency. ~20% [ 5] Dry eye syndrome, also known as keratoconjunctivitis sicca, is the condition of having dry eyes. [ 2] Symptoms include dryness in the eye, irritation, redness, discharge, blurred vision, and easily fatigued eyes. Symptoms range from mild and occasional to severe and continuous. [ 3]
Bromfenac. Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) [ 2] marketed in the US as an ophthalmic solution (brand names Prolensa and Bromday, [ 3] prior formulation brand name Xibrom, which has since been discontinued) by ISTA Pharmaceuticals for short-term, local use. Prolensa and Bromday are the once-daily formulation of ...
Voclosporin. Voclosporin, sold under the brand name Lupkynis, is a calcineurin inhibitor used as an immunosuppressant medication for the treatment of lupus nephritis. [2] [4] It is an analog of ciclosporin that has enhanced action against calcineurin and greater metabolic stability. [5]
Netarsudil. Netarsudil, sold under the brand name Rhopressa among others, is a medication for the treatment of glaucoma. [ 1][ 2][ 3] In the United States, in December 2017, the Food and Drug Administration (FDA) approved a 0.02% ophthalmic solution for the lowering of elevated intraocular pressure in people with open-angle glaucoma or ocular ...
Twice daily in right eye 26 weeks 1.0% No mortality at all doses. After ocular administration, symptoms included hypermia of the bulbar and papebral conjunctiva, white spots in the lens. Dogs Once a day in right eye and orally 13 weeks 2.0% in eye, 7.5 mg/kg/day by mouth No mortality observed. Monkey Once a day in right eye 52 weeks 2.0%