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SARS-related coronavirus is a member of the genus Betacoronavirus (group 2) and monotypic of the subgenus Sarbecovirus (subgroup B). [ 13] Sarbecoviruses, unlike embecoviruses or alphacoronaviruses, have only one papain-like proteinase (PLpro) instead of two in the open reading frame ORF1ab. [ 14] SARSr-CoV was determined to be an early split ...
The nucleocapsid (N) protein is a protein that packages the positive-sense RNA genome of coronaviruses to form ribonucleoprotein structures enclosed within the viral capsid. [ 2][ 3] The N protein is the most highly expressed of the four major coronavirus structural proteins. [ 2] In addition to its interactions with RNA, N forms protein ...
Treatment and management of COVID-19. The treatment and management of COVID-19 combines both supportive care, which includes treatment to relieve symptoms, fluid therapy, oxygen support as needed, [ 1][ 2][ 3] and a growing list of approved medications. Highly effective vaccines have reduced mortality related to SARS-CoV-2; however, for those ...
The COVID-19 pandemic was covered in Wikipedia extensively, in real-time, and across multiple languages. This coverage extends to many detailed articles about various aspects of the topic itself, as well as many existing articles being amended to take account of the pandemic 's effect on them. [ 1] Wikipedia and other Wikimedia projects ...
The function of the spike glycoprotein is to mediate viral entry into the host cell by first interacting with molecules on the exterior cell surface and then fusing the viral and cellular membranes. Spike glycoprotein is a class I fusion protein that contains two regions, known as S1 and S2, responsible for these two functions.
The COVID-19 pandemic in El Salvador was a part of the worldwide pandemic of coronavirus disease 2019 ( COVID-19) caused by severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ). The virus was confirmed to have reached El Salvador on 18 March 2020. [ 4] As of 19 September 2021, El Salvador reported 102,024 cases, 3,114 deaths, and ...
States, territories, and counties that issued a stay-at-home order in 2020. State, territorial, tribal, and local governments responded to the COVID-19 pandemic in the United States with various declarations of emergency, closure of schools and public meeting places, lockdowns, and other restrictions intended to slow the progression of the virus.
t. e. COVID-19 vaccination in mainland China is an ongoing immunization campaign against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in mainland China, in response to the ongoing pandemic in the region . As of July 2022, it is estimated that about 89.7% of the country's population has received a vaccine, and about 56% of the ...