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Alpha blockers work by blocking the effect of nerves in the sympathetic nervous system. This is done by binding to the alpha receptors in smooth muscle or blood vessels. [ 37] α-blockers can bind both reversibly and irreversibly. [ 2] There are several α receptors throughout the body where these drugs can bind.
Alpha-1 blockers are used as second line treatment for high blood pressure. They are not thought to be good as first line treatment because there are other more selective agents, although they can be good for treating men with hypertension and BPH. [ 11 ]
Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke, heart failure, kidney failure and myocardial infarction. Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34% and of ischaemic heart disease by 21%, and can reduce the likelihood of dementia ...
Prazosin, sold under the brand name Minipress among others, is a medication used to treat high blood pressure, symptoms of an enlarged prostate, and nightmares related to post-traumatic stress disorder (PTSD). [ 6] It is an α 1 blocker. [ 6] It is a less preferred treatment of high blood pressure. [ 6] Other uses may include heart failure and ...
As alpha 1 blocker will dilate blood vessels, it lowers the blood pressure. [3] Thus, it contraindicate to patients with a history of orthostatic hypotension and in current use of phosphodiesterase inhibitors. [3] Moreover, alpha 1 blocker should not be given to patients with heart failure since it expands blood volume. [13]
Metoprolol, sold under the brand name Lopressor among others, is a medication used to treat high blood pressure, angina, and a number of conditions involving an abnormally fast heart rate. [ 4] It is also used to prevent further heart problems after myocardial infarction and to prevent headaches in those with migraines. [ 4]
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