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Alpha-1 blocker. Alpha-1 blockers (also called alpha-adrenergic blocking agents or alpha-1 antagonists) constitute a variety of drugs that block the effect of catecholamines on alpha-1-adrenergic receptors. They are mainly used to treat benign prostatic hyperplasia (BPH), hypertension and post-traumatic stress disorder. [ 1]
Alpha blockers work by blocking the effect of nerves in the sympathetic nervous system. This is done by binding to the alpha receptors in smooth muscle or blood vessels. [ 37] α-blockers can bind both reversibly and irreversibly. [ 2] There are several α receptors throughout the body where these drugs can bind.
Adrenergic blocking agents are a class of drugs that exhibit its pharmacological action through inhibiting the action of the sympathetic nervous system [1] in the body. The sympathetic nervous system (SNS) is an autonomic nervous system that we cannot control by will. It triggers a series of responses after the body releases chemicals named ...
Tamsulosin is an alpha blocker and works by relaxing muscles in the prostate. [10] Specifically it is an α 1 adrenergic receptor blocker. [6] Tamsulosin was approved for medical use in the United States in 1997. [6] It is available as a generic medication. [9]
Prazosin, sold under the brand name Minipress among others, is a medication used to treat high blood pressure, symptoms of an enlarged prostate, and nightmares related to post-traumatic stress disorder (PTSD). [ 6] It is an α 1 blocker. [ 6] It is a less preferred treatment of high blood pressure. [ 6] Other uses may include heart failure and ...
Alpha 1 blockers cause vasodilation by relaxing smooth muscles that control blood vessel diameter, leading to lower blood pressure. [1] FDA-approved uses of these drugs include treating conditions like benign prostatic hyperplasia, hypertension, pheochromocytoma, extravasation management, and reversal of local anesthesia.
An adrenergic antagonist is a drug that inhibits the function of adrenergic receptors. There are five adrenergic receptors, which are divided into two groups. The first group of receptors are the beta (β) adrenergic receptors. There are β 1, β 2, and β 3 receptors. The second group contains the alpha (α) adrenoreceptors.
Labetalol is a beta blocker, or an antagonist of the β-adrenergic receptors. It is specifically a non-selective antagonist of the β 1 - and β 2 -adrenergic receptors. [ 17] Labetalol has intrinsic sympathomimetic activity. [ 17] It is also an antagonist of the α 1 -adrenergic receptor, and hence is additionally an alpha blocker.