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Cancer Cell. Cancer Cell provides a high-profile forum to promote major advances in cancer research and oncology. The primary criterion for considering manuscripts is whether the studies provide major advances into answering important questions relevant to naturally occurring cancers. More.
The evolving tumor microenvironment (TME) during all stages of cancer progression is depicted with key representative cell types shown. The TME includes diverse immune cells, cancer-associated fibroblasts (CAFs), endothelial cells, and the extracellular matrix (ECM), among others.
Early in tumor growth, a dynamic and reciprocal relationship develops between cancer cells and components of the tumor microenvironment that supports cancer cell survival, local invasion and metastatic dissemination.
We uncover that tumor cells mimic the anti-inflammatory mechanism of CNS to evade anti-tumor immunity and NAT8L is a potential target to enhance efficacy of anti-cancer agents.
Tumor heterogeneity was traditionally considered in the genetic terms, but it has now been broadened into many more facets. These facets represent a challenge in our understanding of cancer etiology but also provide opportunity for us to understand prognosis and therapy response.
These studies characterize the combined electrophysiological and molecular properties of human glioma cells and describe a cell type in human glioma with unique electrophysiological and transcriptomic properties that may also exist in the non-tumor brain.
Here, by performing a pan-cancer analysis of single myeloid cells from 210 patients across 15 human cancer types, we identified distinct features of TIMs across cancer types. Mast cells in nasopharyngeal cancer were found to be associated with better prognosis and exhibited an anti-tumor phenotype with a high ratio of TNF+ / VEGFA+ cells.
Here, we dissect glioblastoma-to-microenvironment interactions by single-cell RNA sequencing analysis of human tumors and model systems, combined with functional experiments. We demonstrate that macrophages induce a transition of glioblastoma cells into mesenchymal-like (MES-like) states.
Over the last 10 years, numerous studies have profiled human tumors by single-cell RNA-seq. In this perspective, Tirosh and Suva describe the cell states most commonly observed in cancer, highlight insights into cancer biology, and discuss challenges and future directions in single-cell analysis.
Here, we identified a subpopulation of ACKR2 + therapy-resistant tumor cells in human patients with cervical cancer after concurrent chemoradiotherapy (CCRT), and CCRT-induced ACKR2 in tumor cells subsequently promoted CD8 + T cell senescence, resulting in tumor recurrence after therapy.