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The partial thromboplastin time ( PTT ), also known as the activated partial thromboplastin time ( aPTT or APTT ), is a blood test that characterizes coagulation of the blood. A historical name for this measure is the kaolin-cephalin clotting time ( KCCT ), [ 1] reflecting kaolin and cephalin as materials historically used in the test.
The normal range for a healthy person not using warfarin is 0.8–1.2, and for people on warfarin therapy an INR of 2.0–3.0 is usually targeted, although the target INR may be higher in particular situations, such as for those with a mechanical heart valve. If the INR is outside the target range, a high INR indicates a higher risk of bleeding ...
Activated partial thromboplastin time (aPTT) is used for heparin studies and the normal range is 20–36 seconds, depending upon which type of activator is used in the study. [6] Prothrombin time (PT) is used for warfarin studies and the normal values differ for men and women.
The thrombin time ( TT ), also known as the thrombin clotting time ( TCT ), is a blood test that measures the time it takes for a clot to form in the plasma of a blood sample containing anticoagulant, after an excess of thrombin has been added. [ 1] It is used to diagnose blood coagulation disorders and to assess the effectiveness of ...
Fresh normal plasma has all the blood coagulation factors with normal levels. If the problem is a simple factor deficiency, mixing the patient plasma 1:1 with plasma that contains 100% of the normal factor level results in a level ≥50% in the mixture (say the patient has an activity of 0%; the average of 100% + 0% = 50%). [3]
Warfarin. Warfarin is an anticoagulant used as a medication under several brand names including Coumadin. [9] While the drug is described as a "blood thinner", it does not reduce viscosity but rather inhibits coagulation. Accordingly, it is commonly used to prevent blood clots in the circulatory system such as deep vein thrombosis and pulmonary ...
Deep vein thrombosis. Deep vein thrombosis ( DVT) is a type of venous thrombosis involving the formation of a blood clot in a deep vein, most commonly in the legs or pelvis. [ 9][ a] A minority of DVTs occur in the arms. [ 11] Symptoms can include pain, swelling, redness, and enlarged veins in the affected area, but some DVTs have no symptoms. [ 1]
4-6 kDa. Low-molecular-weight heparin ( LMWH) is a class of anticoagulant medications. [ 1] They are used in the prevention of blood clots and, in the treatment of venous thromboembolism ( deep vein thrombosis and pulmonary embolism ), and the treatment of myocardial infarction . Heparin is a naturally occurring polysaccharide that inhibits ...