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Oncogene received a 2024 impact factor of 6.9 and received Journal Citation Reports rankings of 38th out of 245 journals in the category Oncology, 16th out of 175 in the category Genetics & Heredity, 41st out of 194 in the category Cell Biology, and 40th out of 296 in the category Biochemistry & Molecular Biology.
Oncogenesis is a peer-reviewed open access medical journal covering the molecular biology of cancer. It was established in 2012 by Douglas R. Green as a sister journal to Oncogene, of which Green was then editor-in-chief. [ 1] New articles are published exclusively online by Nature Publishing Group on a weekly basis. [ 2]
An oncogene is a gene that has the potential to cause cancer. [ 1] In tumor cells, these genes are often mutated, or expressed at high levels. [ 2] Most normal cells undergo a preprogrammed rapid cell death ( apoptosis) if critical functions are altered and then malfunction. Activated oncogenes can cause those cells designated for apoptosis to ...
Oncogenomics. Oncogenomics is a sub-field of genomics that characterizes cancer -associated genes. It focuses on genomic, epigenomic and transcript alterations in cancer. Cancer is a genetic disease caused by accumulation of DNA mutations and epigenetic alterations leading to unrestrained cell proliferation and neoplasm formation.
Myc family: The Myc family of transcription factors are proto-oncogenes implicated in cancer. Yamanaka et al. and Jaenisch et al. demonstrated that c-myc is a factor implicated in the generation of mouse iPS cells and Yamanaka et al. demonstrated it was a factor implicated in the generation of human iPS cells.
KRAS ( Kirsten rat sarcoma virus) is a gene that provides instructions for making a protein called K-Ras, a part of the RAS/MAPK pathway. The protein relays signals from outside the cell to the cell's nucleus. These signals instruct the cell to grow and divide ( proliferate) or to mature and take on specialized functions ( differentiate ).
e. Illustration of an activator. In molecular biology, a transcription factor ( TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. [ 1][ 2] The function of TFs is to regulate—turn on and off—genes in order ...
Protein c-Fos is a proto-oncogene that is the human homolog of the retroviral oncogene v-fos. [ 5] It is encoded in humans by the FOS gene. It was first discovered in rat fibroblasts as the transforming gene of the FBJ MSV (Finkel–Biskis–Jinkins murine osteogenic sarcoma virus) (Curran and Tech, 1982). It is a part of a bigger Fos family of ...