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Multiple endocrine neoplasia, type 1 (MEN 1), sometimes called Wermer's syndrome, is a rare disorder that causes tumors in the endocrine glands and parts of the small intestine and stomach.
Multiple endocrine neoplasia type 1 (MEN-1) is one of a group of disorders, the multiple endocrine neoplasias, that affect the endocrine system through development of neoplastic lesions in pituitary, parathyroid gland and pancreas. [1] .
MEN1 is an inherited disorder most often caused by a mutation in the MEN1 gene. The gene provides instructions for producing a protein called menin, known to play a role in keeping cells from growing and dividing too fast.
MEN type 1 is caused by mutations of the MEN1 gene. The MEN1 gene is a tumor suppressor gene, meaning it helps prevent tumors from forming by controlling cell division and instructing cells when to die (a normal process).
Menin is a protein that in humans is encoded by the MEN1 gene. [5] Menin is a putative tumor suppressor associated with multiple endocrine neoplasia type 1 (MEN-1 syndrome) and has autosomal dominant inheritance. [6]
Kamilaris CDC, et al. Multiple endocrine neoplasia type 1 (MEN1): An update and the significance of early genetic and clinical diagnosis. Frontiers in Endocrinology. 2019; doi: 10.3389/fendo.2019.00339.
The MEN1 gene provides instructions for making a protein called menin. This protein acts as a tumor suppressor, which means that it keeps cells from growing and dividing too fast or in an uncontrolled way.
Multiple endocrine neoplasia type 1 (MEN1) is a genetic condition that causes benign and malignant tumors in endocrine (hormone producing) and non-endocrine tissues. It occurs in approximately 1 in 30,000 individuals. Endocrine tumors may arise in the: Parathyroid glands (small glands located next to the thyroid gland) Pituitary gland.
Multiple endocrine neoplasia type 1 (MEN1) includes varying combinations of more than 20 endocrine and non-endocrine tumors. Endocrine tumors become evident either by overproduction of hormones by the tumor or by growth of the tumor itself.
MEN 1 is a rare condition, affecting about 1 in 30,000 people. Mayo Clinic specialists treat about 142 people with MEN 1 each year. This experience means your doctors are equipped with the knowledge and resources to provide you with the best care.