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Trastuzumab. Trastuzumab, sold under the brand name Herceptin among others, is a monoclonal antibody used to treat breast cancer and stomach cancer. [20] [17] [21] [22] It is specifically used for cancer that is HER2 receptor positive. [20] It may be used by itself or together with other chemotherapy medication. [20]
The linker group that makes emtansine is shown in blue at right, bound to the amino group (HN–) of a lysine residue in the trastuzumab molecule (–mab). Trastuzumab emtansine is an antibody-drug conjugate (ADC), a combination between a monoclonal antibody and a small-molecule drug. Each molecule of trastuzumab emtansine consists of a single ...
Slamon is a physician scientist at UCLA Medical Center (Los Angeles), where he has developed the experimental drug Herceptin, which he believes will become a treatment for breast cancer. However, when the drug company stops funding the research, philanthropists, including Lilly Tartikoff (Angie Harmon) and Ronald Perelman help him continue drug ...
NCI Drug Dictionary. National Cancer Institute. Clinical trial number NCT00950300 for "A Study to Compare Subcutaneous (SC) Versus Intravenous (IV) Administration of Herceptin (Trastuzumab) in Women With Human Epidermal Growth Factor Receptor (HER) 2-Positive Early Breast Cancer" at ClinicalTrials.gov
July 29, 2024 at 10:27 AM. A life-extending drug for incurable breast cancer will not be made available on the health service in England after its manufacturers and the NHS spending watchdog ...
Trastuzumab deruxtecan, sold under the brand name Enhertu, is an antibody-drug conjugate consisting of the humanized monoclonal antibody trastuzumab (Herceptin) covalently linked to the topoisomerase I inhibitor deruxtecan (a derivative of exatecan ). [11] [12] It is licensed for the treatment of breast cancer or gastric or gastroesophageal ...
June 18, 2024 at 3:06 AM. (Reuters) - AstraZeneca said on Tuesday its breast cancer drug, Truqap, in combination with chemotherapy agent, paclitaxel, did not meet its main goals in a late-stage ...
Breast cancer chemotherapy. A woman being treated with docetaxel chemotherapy for breast cancer. Cold mittens and wine chilling devices are placed on her hands and feet to prevent deleterious effects on the nails. Similar strategies can be used to prevent hair loss. Breast cancer chemotherapy refers to the use of cytotoxic drugs ( chemotherapy ...
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