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  2. Trastuzumab - Wikipedia

    en.wikipedia.org/wiki/Trastuzumab

    Trastuzumab. Trastuzumab, sold under the brand name Herceptin among others, is a monoclonal antibody used to treat breast cancer and stomach cancer. [20] [17] [21] [22] It is specifically used for cancer that is HER2 receptor positive. [20] It may be used by itself or together with other chemotherapy medication. [20]

  3. Trastuzumab deruxtecan - Wikipedia

    en.wikipedia.org/wiki/Trastuzumab_deruxtecan

    Trastuzumab deruxtecan is indicated for the treatment of adults with unresectable (unable to be removed with surgery) or metastatic (when cancer cells spread to other parts of the body) HER2-positive breast cancer who have received two or more prior anti-HER2-based regimens in the metastatic setting and for adults with locally advanced or metastatic HER2-positive gastric or gastroesophageal ...

  4. Tucatinib - Wikipedia

    en.wikipedia.org/wiki/Tucatinib

    Tucatinib, sold under the brand name Tukysa, is an anticancer medication used for the treatment of HER2-positive breast cancer. [3] [4] It is a small molecule inhibitor of HER2. [6] [7] It was developed by Array BioPharma and licensed to Cascadian Therapeutics (formerly Oncothyreon, subsequently part of Seattle Genetics ). [8]

  5. Pertuzumab - Wikipedia

    en.wikipedia.org/wiki/Pertuzumab

    Pertuzumab, sold under the brand name Perjeta, is a monoclonal antibody used in combination with trastuzumab and docetaxel for the treatment of metastatic HER2-positive breast cancer; it also used in the same combination as a neoadjuvant in early HER2-positive breast cancer. [4] Side effects in more than half the people taking it include ...

  6. Trastuzumab emtansine - Wikipedia

    en.wikipedia.org/wiki/Trastuzumab_emtansine

    The linker group that makes emtansine is shown in blue at right, bound to the amino group (HN–) of a lysine residue in the trastuzumab molecule (–mab). Trastuzumab emtansine is an antibody-drug conjugate (ADC), a combination between a monoclonal antibody and a small-molecule drug. Each molecule of trastuzumab emtansine consists of a single ...

  7. Pertuzumab/trastuzumab/hyaluronidase - Wikipedia

    en.wikipedia.org/wiki/Pertuzumab/trastuzumab/...

    The fixed-dose combination is indicated for the treatment of early breast cancer (EBC): Use in combination with chemotherapy for: [8] the neoadjuvant treatment of adults with HER2-positive, locally advanced, inflammatory, or early stage breast cancer (either greater than two cm in diameter or node positive) as part of a complete treatment regimen for early breast cancer; [8]

  8. Breast cancer - Wikipedia

    en.wikipedia.org/wiki/Breast_cancer

    For those whose tumors are HER2-positive, adding the HER2-targeted antibody trastuzumab to chemotherapy reduces the chance of cancer recurrence and death by at least a third. [63] [64] Trastuzumab is given weekly or every three weeks for twelve months. [64] Adding a second HER2-targeted antibody, pertuzumab slightly enhances treatment efficacy ...

  9. Kristen Dahlgren: Why I’m leaving NBC to launch a nonprofit ...

    www.aol.com/news/kristen-dahlgren-why-m-leaving...

    In 2013, Disis and her team made headlines with a promising trial involving 66 women with advanced-stage HER2-positive breast cancer. While this trial was not designed to assess whether the ...

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