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GLP-1 agonists were developed initially for type 2 diabetes. [5] The 2022 American Diabetes Association (ADA) standards of medical care in diabetes include GLP-1 agonist or SGLT2 inhibitor as a first line pharmacological therapy for type 2 diabetes in patients who have or are at high risk for atherosclerotic cardiovascular disease or heart failure.
A new study reports that of the 1 million new GLP-1 medication users identified between 2011 to 2023, there was a twofold increase in GLP-1 medication users who do not have type 2 diabetes.
Dipeptidyl peptidase-4 inhibitor. Inhibitors of dipeptidyl peptidase 4 ( DPP-4 inhibitors or gliptins) are a class of oral hypoglycemics that block the enzyme dipeptidyl peptidase-4 (DPP-4). They can be used to treat diabetes mellitus type 2 . The first agent of the class – sitagliptin – was approved by the FDA in 2006.
Dulaglutide, sold under the brand name Trulicity among others, [6] is a medication used for the treatment of type 2 diabetes in combination with diet and exercise. [7] [8] It is also approved in the United States for the reduction of major adverse cardiovascular events in adults with type 2 diabetes who have established cardiovascular disease or multiple cardiovascular risk factors. [9]
In two studies involving 840 participants with type 2 diabetes, dapagliflozin when used alone decreased HbA 1c levels by 0.66% more than placebo (a dummy treatment) after 24 weeks. [7] In four other studies involving 2,370 participants, adding dapagliflozin to other diabetes medicines decreased HbA 1c levels by 0.54–0.68% more than adding ...
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